In this study, a novel optical immunoassay platform was developed by using an optical probe 2-amino-4-(4-formylphenyl)-4H-chromene-3-carbonitrile (AFC), which was synthesized via greener Ultra-sonication method. The structure of the probe was elucidated through Fourier-Transform Infrared Spectroscopy and Nuclear Magnetic Resonance spectroscopy techniques.

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Abstract A green procedure for the one-pot three-component synthesis of 1-amidoalkyl-2-naphthol and 3-amino-1-phenyl-1H benzo[f]chromene-2-carbonitrile derivatives from the reaction of 2-naphtol, aldehydes, and malononitrile/acetamide in the presence of a catalytic amount of Fe3O4@enamine-B(OSO3H)2 as an efficient and novel heterogeneous magnetic nanostructure catalyst is described.

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The unexpected stereospecific synthesis of (±)-cis-1-aryl-3-oxo-2,3-dihydro-1H-benzo[f]chromene-2-carbonitriles (2) and (±)-trans-4-aryl-2-oxo-3,4-dihydro-2H-benzo[h]chromene-3-carbonitriles (4) from (±)-3-amino-1-aryl-1H-benzo[f]chromene-2-carbonitriles (1) and (±)-2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles (3), respectively, by ...

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A green procedure for the one-pot three-component synthesis of 1-amidoalkyl-2-naphthol and 3-amino-1-phenyl-1H benzo[f]chromene-2-carbonitrile derivatives from the reaction of 2-naphtol, aldehydes, and malononitrile/acetamide in the presence of a catalytic amount of Fe 3 O 4 @enamine-B(OSO 3 H) 2 as an efficient and novel heterogeneous magnetic nanostructure catalyst is described.

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It was observed that in the absence of the catalyst, reaction of resorcinol (1) with 4-methylbenzaldehyde (2e) and malononitrile (3a) led to only trace amounts of 2-amino-7-hydroxy-4-(p-tolyl)-4H-chromene-3-carbonitrile (4e) after 10 h at room temperature (RT) and 50 °C (entries 1 and 2).When the reaction was performed using 2.5 mol% KHP in water, product formation was observed …

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ing method to construct the 2-amino-4H-chromene skeleton. 2. Experimental 2.1 Materials and methods Solvents used were of analytical grade. All melt-ing points were taken in open capillaries and are uncorrected. Thin-layer chromatography (TLC, on alu-minium plates precoated with silica gel, 60F254, 0.25mm thickness) (Merck, Darmstadt, Germany) was

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A method of making an optical element (10) that includes a thermoplastic power portion (12), the method including laminating a first thermoplastic sheet (22) to one side of a functional film (21), laminating a second thermoplastic sheet (24) to a second side of the functional film (21), and affixing either the first thermoplastic sheet (22) or the second thermoplastic sheet (24) to the power ...

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Several methods have been reported for the synthesis of pyrano[3,2-c]chromene derivatives. 2-Amino-4-aryl-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitriles have previously been prepared from aromatic aldehydes, malononitrile, and 4-hydroxycoumarin in the presence of organic bases like piperidine or pyridine in an organic solvent, that is ...

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Synthesis of Type 2 chromene peptidomimetics 5: Our study was extended to the randomization of alkynes 1 with (beta )-amino acid residues 4a–f to obtain the Type 2 peptidomimetics. The azide-functionalized (beta )-amino acid type peptide residues 4a–f were obtained from a two-step process comprising of an initial Mannich type four-component reaction [53,54,55,56,57,58] followed by …

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Table 1: 3-amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile 4a–g in under grinding using DABCO Yields refer to pure isolated products characterized b y IR, 1 H and 13 C N MR spectroscopy and mass spectrometry. The structures of compounds 4 were deduced from their 1 H NMR, 13 C NMR and IR spectral data and their molecular weight confirmed by mass spectrometry.

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Abstract An easy solvent-free method is described for the synthesis of 3,4-dihydropyrano[c]chromenes by a one pot three component coupling reaction of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin using basic ionic liquid as the catalyst by grindstone chemistry. The salient features of this one pot protocol are short reaction times, cleaner reaction profiles and simple workup.

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An efficient and environmentally benign method has been developed for the synthesis of 2-amino-4H-chromene derivatives via one-pot multi component condensation of resorcinol (1), malononitrile (2), and various aromatic aldehydes (3a–j), using highly monodisperse palladium nanoparticles supported with graphene oxide ([email protected]) as a heterogeneous catalyst.

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A convenient and efficient method using microwave assisted one pot synthesis reactions for synthesis of 4H-benzo[f]chromenes by the reaction of aromatic aldehydes with a mixture of malononitrile ...

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A Greener Synthesis of 2-Aminochromenes in Ionic Liquid and Evaluation of Their Antiproliferative Activities ... An improved simple and facile synthesis of chromene derivatives by employing three- ... Among different types of chromene systems, 2-amino-4H-chromenes are of particular

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Expeditious Synthesis of 2-Amino-4H-chromenes and 2-Amino-4H-pyran-3- carboxylates Promoted by Sodium Malonate ... Highly Efficient and Regioselective Synthesis of a Novel Pyrrole- Linked benzo[f]chromene Scaffold in a Green Media. ... Operationally Simple and Efficient Synthesis of 7-Benzylidene-substitutedphenyl- 3,3a,4,5,6,7-hexahydro-2H ...

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Grinding – 4 [92%] 2: ... (2-amino-4H-benzo[f]chromene-3-carbonitrile). xan as a source of formaldehyde reacted to 2-naphthol and malononitrile. ... We have demonstrated a simple method for the synthesis of 2-amino-4H-benzochromene-3-carbonitrile by nano-TiCl 4.SiO 2 as efficient catalyst under solvent-free condition. The antibacterial ...

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A simple, e cient and one-pot method has been developed for the synthesis of densely functionalized aryl derivatives of 2-amino-3-cyano-7-hydroxy-4H-chromene by the domino Knoevenagel-Michael-cyclization reactions of aromatic aldehydes, resorcinol and malononitrile in the presence of a catalytic amount of Na2CO3 under grinding conditions.

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The solvent-free reaction of salicylaldehyde 1a, malononitrile and 4-hydroxy-6-methyl-2H-pyran-2-one without catalyst in a reaction time of 15 min (entry 1, Table 2) resulted in the formation of 4-pyrano-substituted 2-amino-4H-chromene 2a in only 26% yield. In the presence of 10 mol % of NaOAc as a catalyst, 2-amino-4H-chromene 2a was obtained in 60% yield (entry 2, Table 2).

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Ball milling for the quantitative and specific solvent-free Knoevenagel condensation + Michael addition cascade in the synthesis of various 2-amino-4-aryl-3-cyano-4 H-chromenes without heating†. Omid Hosseinchi Qareaghaj a, Sara Mashkouri a, M. Reza Naimi-Jamal * a and Gerd Kaupp b a Research Laboratory of Green Organic Synthesis and Polymers, Department of Chemistry, Iran University of ...

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A series of 1 H -benzo[ f ]chromene-2-carbonitriles was synthesized and evaluated for their cytotoxic activities against MCF-7, HCT-116, and HepG-2 cancer cells. The SAR studies reported that the substitution in the phenyl ring at 1-position of 1 H -benzo[ f ]chromene nucleus with the specific group, H atom, or methoxy group at 9-position increases the ability of the molecule against the ...

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substrates. By using this method, different kinds of various aromatic aldehydes compounds were reacted with malononitrile or ethyl cyanoacetate an d phenols to produce the corresponding chromenes derivatives under reflux conditions (Table 2). Table. 2. One-pot synthesis of ethyl-3-amino-1-aryl-1H-benzo[f]chromeme-2-carboxylate

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A method of making an optical element that includes a thermoplastic power portion, the method including laminating a first thermoplastic sheet to one side of a functional film, laminating a second thermoplastic sheet to a second side of the functional film, and affixing either the first thermoplastic sheet or the second thermoplastic sheet to the power portion, with the other of the first or ...

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Olyaei et al. reported the synthesis of a new class of benzo[f]chromene derivatives 97 in good yields (78–85%) (Scheme 30). They introduced a one-pot three-component condensation reaction of 2,3-dihydroxynaphthalene 95, malononitrile 2 and aromatic aldehydes 7 using guanidine hydrochloride 96 as the catalyst under solvent-free conditions .

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in the synthesis of chromene and pyran derivatives 1-4 via three-component reaction of enolic or phenolic com-ponent, such as dimedone, -naphthol, -naphthol, or kojic acid, with malononitrile and aromatic aldehydes (Scheme 1). 2. Experimental 2.1. Material and methods FeCl36H2O, FeCl24H2O, glycine, and all other chem-

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An eco-friendly and efficient straightforward method has been developed for the synthesis of ethyl 3-amino-1-aryl-1H-benzo[f]chromene-2-carboxylate derivatives via 1,4-diazabicyclo[2.2.2]octane ...

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2. Experimental2.1. General. All chemicals used were of commercial grade and were used without any further purification. Melting points were determined using a μThermoCal 10 (Analab scientific Pvt. Ltd.) melting point apparatus and are uncorrected. TLC was carried out using aluminum sheets precoated with silica gel 60 F 254 (Merck). IR spectra were recorded on a FTIR Perkin Elmer …

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amino benzo f chromene ball mill method; electrical equipment used in mining; and washing plant in south africa; ball mill and magnetic separator machine; butterfly table top grinder models and prices in chennai; 200 250tph stone crushing plant in africa; heat resistant rubber sheet thin rubber sheet; copper classifier type wtjc 123 pdf jakarta

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In the last decade numerous methods have been developed for the synthesis of 4 H-benzo[b] ... pyrazole derivatives by a grinding method under solvent-free conditions Synthetic ... and simple organocatalyst for the one-pot three-component synthesis of various 2-amino-4H-chromene derivatives in water Tetrahedron 2013 69 3 1074 1085 10.1016/j.tet ...

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A novel method for the synthesis of 2-imino-2H-benzo[h]chromenes via the sequential addition of N-chlorosuccinimide and triethylamine to 2-amino-4H-benzo[h]chromenes has been established.This reaction protocol represents an efficient synthetic strategy to form iminochromene derivatives under mild reaction conditions, which utilizes readily accessible aminochromenes as …

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A series of 2-aminochromene derivatives including 2-amino-benzo [h] chromene, 2-amino-benzo [f] chromene and 2-aminopyrano [3,2-h]quinolin derivatives was synthesized from arylaldehyde ...

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